Abstract
Objectives. To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants. Methods. A systematic literature search of peer-reviewed English language articels using PubMed (www.pubmed.org) was performed.Results. Comprehensive evidence on the infl uence of serotonergic genes ( SLC6A4, HTR1A, MAOA, TPH2) and BDNF onthe following neural intermediate phenotypes is displayed: amygdala reactivity, coupling of amygdala-anterior cingulatecortex (ACC) activity, ACC volume, hippocampal volume and serotonin receptor 1A (5-HT1A) binding potential (BP).Conclusions. Intermediate phenotypes may bridge the gap between genotype and phenotype by reducing the imprecisenessof psychiatric phenotypes and yield more insights into the underlying biology.
Key words: Major depressive disorder, genetics, pharmacogenetics, amygdala, cingulate gyrus, hippocampus, 5-HT1A receptor
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Image taken from the article by Scharinger et al. (2011)
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